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Shimizu and Sano reported six cases of Takayasu arteritis in an English-language publication in 1951, terming the disorder "pulseless disease because of an absence of radial pulse in their patients.This led to a misunderstanding ot Takayasu arteritis as a disorder of only locally limited involvement.Rarely, Takayasu arteritis has also been associated with glomerulonephritis, systemic lupus, polymyositis, polymyalgia rheumatica, rheumatoid arthritis, Still disease, and ankylosing spondylitis.

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Advanced lesions demonstrate a panarteritis with intimal proliferation.Patients with Takayasu arteritis were found to have higher immunoglobulin G (Ig G), immunoglobulin M (Ig M), and immunoglobulin A (Ig A) titers against the In Japanese patients, human leukocyte antigen Bw52 (HLA-Bw52), which is in linkage disequilibrium with human leukocyte antigen DR4 (HLA-DR4), has been observed with increased frequency.Patients with the Bw52 genotype had a higher rate of aortic regurgitation.Takayasu arteritis can manifest as isolated, atypical, and/or catastrophic disease.

It can involve any or all of the major organ systems.

His patient was a 21-year-old woman with coronary anastomosis of the retinal vessels.